Role of Interleukin (IL)-18 in experimental paracoccidioidomycosis
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چکیده
منابع مشابه
Role of interleukin-18 (IL-18) in mycobacterial infection in IL-18-gene-disrupted mice.
Immunity to mycobacterial infection is closely linked to the emergence of T cells that secrete cytokines, gamma interferon (IFN-gamma), interleukin-12 (IL-12), and tumor necrosis factor alpha (TNF-alpha), resulting in macrophage activation and recruitment of circulating monocytes to initiate chronic granuloma formation. The cytokine that mediates macrophage activation is IFN-gamma, and, like IL...
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Interleukin-18 (IL-18) is a member of the IL-1 family of cytokines. Similar to IL-1β, IL-18 is synthesized as an inactive precursor requiring processing by caspase-1 into an active cytokine but unlike IL-1β, the IL-18 precursor is constitutively present in nearly all cells in healthy humans and animals. The activity of IL-18 is balanced by the presence of a high affinity, naturally occurring IL...
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Interleukin 18 (IL-18) is a pleiotropic cytokine involved in the regulation of innate and acquired immune response. In the milieu of IL-12 or IL-15, IL-18 is a potent inducer of IFN-gamma in natural killer (NK) cells and CD4 T helper (Th) 1 lymphocytes. However, IL-18 also modulates Th2 and Th17 cell responses, as well as the activity of CD8 cytotoxic cells and neutrophils, in a host microenvir...
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These include: References http://ard.bmjjournals.com/cgi/content/full/62/suppl_2/ii48#BIBL This article cites 19 articles, 14 of which can be accessed free at: Rapid responses http://ard.bmjjournals.com/cgi/eletter-submit/62/suppl_2/ii48 You can respond to this article at: service Email alerting top right corner of the article Receive free email alerts when new articles cite this article sign u...
متن کاملThe Role of Interleukin (IL-22) in immune response to human diseases
Background and aims: IL-22 is an alpha- helical cytokine. IL-22 binds to a heterodimeric cell surface receptor composed of IL-10R2 and IL-22R1subunits. IL-22R is expressed on tissue cells, and it is absent on immune cells. L-22 and IL-10 receptor chains play a role in cellular targeting and signal transduction to selectively initiate and regulate immune responses. The aim of this study was to i...
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ژورنال
عنوان ژورنال: Medical Mycology
سال: 2008
ISSN: 1369-3786,1460-2709
DOI: 10.1080/13693780801895444